I'm only going to mention the Bon Iver similarity once just to get it the fuck out of the way, so think it once, and then put that shit out ya brain, because this is better than a "it sounds like...".
"In Your Blood" from Thom Byles is some motherfuckin' hot chocolate right the fuck now. The emotion this dude thumbslaps his acoustic guitar with is fucking gut wrenching. While the guitar is on a steady paced meter set to soothe, the percussive aspects of this song are captivating as fuck. Normally when you're looking to layer a song with vocals, the layered aspects are the focus for the listener, but while it starts out like that, the gradual move towards that drummed rhythm is gorgeous. And while I didn't notice all of the reverb on the guitar at first, holy shit, WAS THIS RECORDED IN A CAVERN THE SIZE OF MY LIBIDO?
Thom Byles has managed to take a simple pick out, paired it with a simple vocal, but then complicated the entire meal by beautifully and delicately harmonizing until your eyes are completely closed, and then there's a snare and you aren't just sitting with your eyes closed. Once that drum hits you're Ray Charlesing the shit out of yourself.
Regardless of what you might look like when you silently seize from a song as perfect as this, I think this song makes you look more honest with yourself.
Unless of course this song does nothing for you, because in that case, you're a fucking dick and everyone knows it.